State legal reps ask Commissioner Hamburg to overturn the approval.
Updates include responsive design and information in Spanish.
The changes, which include tightening prescribing criteria of extended-release and long-acting opioids and a boxed warning for pregnancy, are part of an effort to curb abuse. Some said the FDA's effort is too limited
Phase II studies found recreational abusers were not significantly bothered by the mechanism meant to make a "deterrent" version unpleasant to snort.
The drugstore chain says it has cut off over-prescribers of tightly controlled medications.