Analyst report concludes Tysabri/Avonex combo might have lead to deaths

Share this article:
Biogen Idec and Elan's multiple sclerosis drug Tysabri may have killed patients because of an adverse interaction with the Biogen multiple sclerosis drug Avonex, according to an investors from Ireland's NCB Stockbrokers.
The investors' note, written by NCB analyst Orla Hartford, said an interaction of Tysabri and Avonex "essentially leads to almost double the intended Tysabri concentration after only 20 weeks. . . Patients on Tysabri alone did not accumulate the drug."
Hartford based her findings on analyzed data submitted to the FDA during the approval process.
A spokeswoman for Elan told Bloomberg News the company is "continuing with the review (of Tysabri) and will comment when it has been completed."
Biogen Idec and Elan told MM&M earlier this year that they expect to issue a decision on Tysabri in the second half of 2005.
Tysabri was removed from the market in March after being linked to progressive multifocal leukoencephalopathy, a rare neurological disease most often found in patients with compromised immune systems. Hartford said in the Bloomberg News report that the Tysabri accumulation may have led to a suppressed local immune system partially because the body is less able to process it, which leads to an overdosing.
Share this article:
You must be a registered member of MMM to post a comment.

Next Article in Business Briefs

Email Newsletters


Patient access to pharmaceuticals is a tale of two worlds—affordability has improved for the majority, while the minority is hampered by cost, distribution and red tape. To provide marketers with a well-rounded perspective, MM&M presents this e-book chock full of key insights. Click here to access it.

More in Business Briefs

Novartis said to be stepping out of HCV

Novartis is said to have relinquished rights to an investigational hep. C treatment, signaling its exit from the therapeutic space, according to a former partner's announcement.

Monday Moves: September 15

Hires and promotions for manufacturers, regulatory and agencies

Kantar acquires Evidências, expands Brazilian presence

The company's acquisition signals the growing importance of understanding the Brazilian healthcare market and evidence-based healthcare management services.