Medivation's Xtandi could eat into Zytiga turf

Share this article:
Therapeutic Focus 2013: Oncology
Therapeutic Focus 2013: Oncology

If Credit Suisse's KOLs are correct about prostate cancer drug Xtandi's latest clinical trial news, a change could be afoot for rival prostate drug Zytiga, which is sold by Johnson & Johnson's Janssen subsidiary.

Medivation and Astellas released Phase-III results Tuesday indicating that using Xtandi before chemotherapy let patients put off chemo for an additional 17 months, compared to the placebo group, and that pre-chemo Xtandi bought some progression-free time—at 11.2 months, compared to the placebo group, which saw cancer expand at 2.8 months. Xtandi is currently indicated for use after chemo. Zytiga already has FDA approval for use before or after treatment with chemo.

Phase-III results also indicated that prostate-specific antigen levels fell by at least 50% among 75% of the test group, and overall survival was 29% greater with pre-chemo use compared to placebo. The study notes that this was “despite substantial use of subsequent therapies.”

“The data looks to us about as good as it gets across the board,” Credit Suisse analyst Lee Kalowski wrote in a Wednesday research note. Kalowski did note one drawback, which is that the pre-treat scenario is tied to 17 months of treatment, whereas J&J's Zytiga's pre-chemo therapy is a 14-month cycle.

In addition to having safety data that “overall looks clean,” Kalowski wrote that urology experts tell the analyst firm they “expected to use Xtandi first in all pre-chemo patients,” were the FDA to green-light the new indication. These experts also told Credit Suisse that doctors are generally adhering to the pre- and post-chemo limits of each of these medications.

Oncologists are looking at the results a little differently, focusing on the overall survival curve, but they, too, appear to be aligned with the drug's import. “One oncologist noted to us in December that an early separation would indicate to him that Xtandi is the product that should be used earlier in the disease state,” Kalowski wrote, indicating the split between overall survival rates for Xtandi and Zytiga.

Medivation and Astellas said in a statement they plan to file for the new indication with the FDA and EU in the first half of this year.

Share this article:
You must be a registered member of MMM to post a comment.


Patient access to pharmaceuticals is a tale of two worlds—affordability has improved for the majority, while the minority is hampered by cost, distribution and red tape. To provide marketers with a well-rounded perspective, MM&M presents this e-book chock full of key insights. Click here to access it.

More in Channel

Five things for pharma marketers to know: Monday, September 15

Five things for pharma marketers to know: ...

Pharma has sought 76 meetings with FDA over biosimilars; Gilead licenses Sovaldi to India generic drugmakers; Pfizer and Ranbaxy Lipitor lawsuit dismissed.

Liraglutide, aiming for new indication, gets new name

Liraglutide, aiming for new indication, gets new name

Why Novo Nordisk is choosing not to leverage Victoza's brand equity as it seeks a weight-loss indication for liraglutide.

Five things for pharma marketers to know: Friday, September 12

Five things for pharma marketers to know: Friday, ...

An FDA panel voted in favor of liraglutide for weight loss; Allergan investors backing an attempted takeover of the firm crossed a critical threshold; and 100 million health wearables are ...