Pfizer's PCSK9 meets Phase-II primary endpoint

Share this article:

Pfizer has issued the results of its Phase-II trial for PCSK9 cholesterol lowering treatment bococizumab (RN316). The drugmaker said the study met its primary endpoint across all doses, “showing that bococizumab significantly reduced lipoprotein cholesterol (LDL-C) from baseline compared to placebo in adults with high cholesterol also taking statin therapy."

Patients were either dosed twice monthly, or once monthly. Both groups “were associated with significant placebo-adjusted reductions in LDL-C” by week 12 of therapy, the drugmaker stated.

Pfizer's global medicines development lead, Dr. Steven Romano, said “we are pleased with the outcome of this Phase 2b study and continue to maintain focus on developing our Phase-III program, which includes two CV outcome studies in populations at high risk from cardiovascular events. Recent guidelines emphasize the reduction of CV risk as the primary goal of lipid therapy" for those patients, he added. The drug's Phase-III trial began in October 2013.

Share this article:
You must be a registered member of MMM to post a comment.
close

Next Article in Business Briefs

Email Newsletters

More in Business Briefs

Apple selfies spur diabetes donations

Jazz apples has launched a Crunch to Contribute campaign to raise money for one of two diabetes associations.

Baxter seeks Cambridge, Mass. HQ

Illinois may be tempted to offer tax incentives for the firm to stay put.

FDA wants Alexion to clean up

FDA inspectors have cited the manufacturer of the rare-disease drug Soliris (eculizumab) for poor manufacturing practices.