Smooth sailing so far for AbbVie's GT1 HCV combo

Share this article:
AbbVie released the first Phase III results from its SAPPHIRE-1 study, which is investigating its multi-drug hepatitis C combo with ribavirin in genotype 1 patients. Patients who had not yet received therapy saw an SVR12 rate of 96%. GT-1 is the most prolific type of HCV worldwide. The company confirmed that it is on track for “major regulatory submissions” in the second quarter of 2014.

Gilead's candidate sofosbuvir—which is slated to receive an approval decision Dec. 8—recently received an FDA advisory panel's full support for use in GT-1 infection, along with interferon and ribavirin.

Merck, too, has a dog in the fight. Its protease inhibitors MK-5172 and MK-8472 are currently undergoing testing in Phase II trials for GT-1. ISI Group analyst Mark Schoenebaum noted earlier this month that the drug may be only 18 months behind Gilead in the race for the first all-oral treatment for GT1.

Share this article:
close

Next Article in Business Briefs

Email Newsletters

More in Business Briefs

Illumina inks deal with J&J, AstraZeneca, Sanofi

The goal is to develop companion diagnostics to match patients with cancer treatments.

Abbott deal highlights inversion inaction

Political furor over the recent spate of tax inversions is having little influence on how the government chooses its partners.

Allergan reported to seek out Salix deal

The Wall Street Journal says the deal would add "another layer of intrigue" to the Allergan-Valeant hostilities.