Study finds nearly one-third of journal research contradicted

Share this article:

Nearly one-third of the results of major studies published in three of the top medical journals between 1990 and 2003 have been refuted, according to a report in Wednesday's Journal of the American Medical Association (JAMA).
"Contradicted and potentially exaggerated findings are not uncommon in the most visible and most influential original clinical research," said John Ioannidis, author of the report and researcher at the University of Ioannina in Greece.
Ioannidis examined research appearing in the New England Journal of Medicine (NEJM), JAMA and The Lancet.
He found that subsequent research contradicted results of seven studies – 16 percent of his sample  – and reported weaker results for seven others.
The contradicted studies dealt with a wide range of drugs and treatments – for instance Vitamin E pills have not been shown to prevent heart attacks, contrary to initial results.
"The crazy part about science and yet the exciting part about science is you almost never have something that is black and white," Catherine DeAngelis, JAMA's editor-in- chief, told the Associated Press.
Editors at NEJM added in a statement: "A single study is not the final word, and that is an important message."


Share this article:
You must be a registered member of MMM to post a comment.


Patient access to pharmaceuticals is a tale of two worlds—affordability has improved for the majority, while the minority is hampered by cost, distribution and red tape. To provide marketers with a well-rounded perspective, MM&M presents this e-book chock full of key insights. Click here to access it.

More in Media

Five things for pharma marketers to know: Wednesday, October 22

Five things for pharma marketers to know: ...

Novo partners with YouTube star for diabetes vids; hedge fund wants Amgen to split up; J&J ramps up Ebola vaccine production.

Mucinex gets a revamp

Mucinex gets a revamp

After 10 years of "Mucinex In. Mucus Out," the congestion-relief treatment gets a new look from Reckitt Beckinser's recently appointed AOR McCann New York.

Mixed reaction to a health-centric Facebook feature

Mixed reaction to a health-centric Facebook feature

The ACLU is among those questioning the positives of the rumored healthcare effort.