Trial results cloud future of Pfizer's torcetrapib

Share this article:
Pfizer confirmed yesterday that its leading pipeline candidate torcetrapib raised blood pressure in clinical trial patients more than previously reported. Pfizer said new analysis showed that torcetrapib raised patients’ systolic blood pressure, the top number of the blood pressure reading, an average of three to four millimeters. Earlier Pfizer studies indicated a blood pressure increase of two to three millimeters. Pfizer is conducting a 25,000 patient trial to determine whether torcetrapib reduces deaths and heart attacks but full data from the trial is not expected until 2009. The findings released yesterday were preliminary results from more than 4,000 patients already enrolled in the trial. The next release of trial results is expected to occur in March at a meeting of the American College of Cardiology. Pfizer is staking much of its future on treatments for cholesterol and cardiovascular disease. The firm is spending close to $800 million on clinical tests of torcetrapib, which raises good cholesterol known as HDL. Pfizer hopes torcetrapib will be able pick up where cholesterol-fighting drug Liptior leaves off. Lipitor, the world’s best-selling prescription drug with over $12 billion in global sales last year, faces generic competition as early as 2010. If regulators approve torcetrapbib, Pfizer could sell the drug alone as well as in combination with Lipitor. The company believes a combination drug could reverse the buildup of the plaque that can build up and blocking blood vessels, leading to heart attacks and strokes.
Share this article:
close

Next Article in Business Briefs

Email Newsletters

More in Business Briefs

Illumina inks deal with J&J, AstraZeneca, Sanofi

The goal is to develop companion diagnostics to match patients with cancer treatments.

Abbott deal highlights inversion inaction

Political furor over the recent spate of tax inversions is having little influence on how the government chooses its partners.

Allergan reported to seek out Salix deal

The Wall Street Journal says the deal would add "another layer of intrigue" to the Allergan-Valeant hostilities.