2015 Top 20 Companies: Shire
20. Shire $5B ▲up 18.6% Global revenue: $6B (24th), up 22%Top brands: Vyvanse ($2.1B)Promotional spend: $139.7M (29th); 2.8% of rev.R&D spend: $566M (20th); down 39.3%; 9.4% of rev.Planned launches: SHP555 (constipation); Lifitegrast (dry eyes); SHP 465 (ADHD)Patent expirations: Intuniv (2015); Firazyr (2015); Carbatrol (2016); Fosrenol (2018) After Shire fended off an AbbVie takeover, analysts said…