Panel chair Randall Flick said QRxPharma "had not provided sufficient evidence to support a claim that Moxduo is safer than morphine or oxycodone."
But demand for Enbrel and Aranesp slipped.
The FDA designation is for an experimental, inhaled form of ciprofloxacin intended to treat a rare lung condition.
The candidate would be the first to put oxycodone and morphine in one capsule.
AbbVie's all-oral HCV treatment filed off six Phase-III trials spanning 25 countries and 2,300 patients
Ramucirumab received FDA approval today in advanced gastric cancer, a nod that could translate into $600 million in peak sales.
The three drugmakers rearranged part of the pharma universe Tuesday with a string of pipeline-altering deals.
The deal would bring Allergan's Botox and Juvederm under the same roof as Restylane.
The rumored $101 billion bid would give Pfizer a foothold in imuno-oncology and diabetes.
Officials are asking users to change passwords, as an added precaution.